IRL 2500 ( —— )

产品货号. M26720 CAS No. 169545-27-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

IRL 2500
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

IRL 2500 is an effective antagonist of the Endothelin receptor. IRL 2500 suppresses ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo.
产品描述

IRL 2500 is an effective antagonist of the Endothelin receptor. IRL 2500 suppresses ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo. IRL 2500 displays (IC50:1.3 and 94 nM for ETB and ETA receptors, respectively).(In Vivo):In the anesthetized rat, IRL 2500 (10 mg/kg; i.v.) decreases the IRL 1620-mediated enhances renal vascular resistance. IRL 2500 suppresses the initial transient reduction in mean arterial pressure induced by IRL 1620. IRL 2500 (10 mg/kg; i.v.) pre-treatment reduces the initial vasodepressor response to endothelin-1 and IRL 1620 without altering the secondary and sustained pressor response.
同义词

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通路

Others
靶点

Other Targets
受体

EGFR
研究领域

——
适应症

——

CAS Number

169545-27-1
分子量

573.7
分子式

C36H35N3O4
纯度

>98% (HPLC)
溶解度

——
SMILES

CN([C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O)C(=O)c1cc(C)cc(C)c1
化学全称

——

1.Ramanadham Jyothi Prasad, et al. 6-7,dialkoxy quinazoline derivatives useful for treatment of cancer related disorders. US 8143250 B2

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